Web conférence du lundi 7 décembre : La troisième voie du développement : le in silico !

Lundi 7 décembre 12h30-14h30
Après le développement des médicaments grâce à des essais in vitro, ex vivo et in vivo, les nouvelles technologies (gestion du big data, algorithmes, intelligence artificielle, objets connectés) font émerger la troisième voie, le « in silico » (sur ordinateur).
Les orateurs vont nous montrer l’impact du « in silico » sur le développement pré-clinique et nous montrer que les essais cliniques se font, en partie, avec des patients virtuels. Ces processus sont désormais encouragés et  évalués par les Agences, aussi bien pour le domaine des médicaments que pour les dispositifs médicaux.
Cécile ROUSSEAU est titulaire d’un doctorat. en génie médical et biologique. 
Après divers postes en tant que responsable non clinique dans la recherche universitaire, l’industrie médicale (LEICA BIOSYSTEMS au USA)  et en biotechnologie (ORGANOGENESIS), Cecile travaille chez VCLS en tant que directrice réglementaire non clinique avec une activité axée sur les thérapies cellulaires et géniques, les dispositifs médicaux, les produits combinés et les produits à base de microbiome. 
Elle appartient au groupe de travail VCLS In Silico et soutient activement les activités de VCLS autour de la modélisation et de la simulation des essais cliniques en travaillant avec les clients et en les préparant dans leurs interactions avec la FDA et l’EMA.
 
 
Cecile CROZATIER est titulaire d’un doctorat. en Micro et Nano-bioingénierie, d’un Master of Science à Polytechnique, d’un Post Doc à Normale Sup et à l’université de Kyoto au japon.
Elle a acquis ensuite une expérience de business development dans l’industrie pharmaceutique chez NOVARTIS puis dans la structure INSERM TRANSFERT.
Elle a rejoint VCLS et est actuellement directrice exécutif des opérations (COO) et coordonne les activités de VCLS autour de la modélisation et de la simulation des essais cliniques soutenant les clients, grâce à des interactions avec la FDA et l’EMA.

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  208. Soccer is the known kind of sport. the main rule to score
    with the ball into the gates of the opposing team’s, using in this case
    all limbs except the arms. Victory goes to the athletes scores more goals .
    Football appeared in 1863. England is considered the birthplace of football .

    Soccer History

    Goal-based entertainment appeared in BC. Game were amusement and
    entertainment. 100 years ago played only by students. There were no unified rules.
    Somewhere do not handle the ball. Somewhere it was allowed to throw the ball with the
    fingers.
    In 1846 organized first soccer competition .

    In England teams from five colleges met .
    Players selected arbitrators and came up with general requirements.
    In 1857 created the first national football team.
    20 years negotiations in the world sports association .

    Only in 1971 approved the regulations, the size of the goal
    and the structure of the ball were approved . In the same
    year the first football matches in the framework of the FA Cup took place .

    In 1891 the rules began to supplement . The term « Penalty » appeared .
    It was used by as a punishment for playing not by the rules.

    How football became a famous sport

    Football became really popular in 1880. The number of cubes within the football association has reached 100 pieces .

    Previously, football was an amateur sport, but in the 80s, players started to get paid .
    The international community reacted negatively to monetary relations .
    For footballers those receiving money were
    not allowed to represent the country at major matches, and
    club, breaking the rule , removed from association. 5 years
    later footballers allowed to receive money for sports achievements .
    In the same year the world’s first football league appeared , calling its
    players professional workers .When football became popular

    Fame came to football in 1880. The number of cubes within the
    football association has reached 100 pieces . Previously, football was
    an amateur sport, but in the 80s, players started
    to get paid . Society did not want to accept money games.

    For footballers those receiving money banned from representing the country in national competitions , and club, seen paying money,
    expelled from association . In 1885 footballers allowed play
    for a reward. at the same time created a soccer league, calling its
    players professional workers .

    In 1872 ended national football tournament has ended.
    In it took part players from England and Scotland.

    In 1904 the football association called a convention in France.
    Members decided to reorganize the organization . So, it appeared popular company Fifa.
    Initially, the national games were called the Olympic
    Games. When Fifa appeared, international tournaments began to
    be called the World Cup. The tournament is now called the YEFA Cup.

    The team from Uruguay was the winner. The tournament takes place every 2
    years. In 2020 Due to the Covid-19 outbreak the game has been canceled for the first time.

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  211. Soccer is the known kind of sport. the goal of the game hit the ball into
    the gates of opponents, applying any part of the body except the arms.
    Victory wins the team that who made more throws. Football appeared
    in 1863. The game originated in the UK.

    Soccer History

    Ball games used in ancient Greece, Rome, and China. Game were purely for entertainment .
    100 years ago played only by students. There were no general rules.
    Somewhere it was strictly forbidden to touch the ball with your hands .
    In a number of states, on the contrary, it was possible to transfer
    by hand .
    In 1846 organized a real football tournament. In England teams from five colleges met .
    Athletes appointed a jury and came up with general requirements.
    In 1857 the first professional club of Sheffield was established
    . 20 years negotiations in the world sports association .
    Only in 1971 approved the regulations, the size of the
    goal and the structure of the ball were approved .
    In the same year the FA Cup was organized. In 1891 new
    provisions appeared. The term « Penalty » appeared .
    The throw was appointed as a punishment for playing not
    by the rules.
    popularization of football

    Football became really popular in 1880. The number of cubes within the football association has reached 100 pieces .
    If in the beginning it was an entertaining game , but in the 80s, players started to get paid .

    Society did not want to accept money games. For players
    those receiving money banned from representing the country in national competitions , and club, breaking the rule , removed from association.
    5 years later footballers allowed play for a reward.
    In the same year created a soccer league, its members became footballers.
    How football became a famous sport

    Fame came to football in 1880. The association includes more than 100 clubs.
    Previously, football was an amateur sport, but in the 80s,
    players started to get paid . The international community reacted negatively to monetary
    relations . For footballers on salary were not allowed to represent the country at major matches, and team , breaking the rule ,
    removed from association. 5 years later players
    allowed to receive money for sports achievements .

    In the same year the world’s first football league appeared , its members became
    footballers.

    In 1872 the first national football match has ended.
    In game took part players from England and Scotland. In 1904 the football association held a meeting in Paris .
    Members made a decision to reorganize the organization .
    So they created the famous Fifa . Initially,
    the national games were called the Olympic Games. When Fifa appeared,
    international tournaments began to be called
    the World Cup. The tournament is now called the YEFA Cup.
    The team from Uruguay was the winner. The tournament takes place
    every 2 years. In 2020 due to the global pandemic the competition has been rescheduled for the next year .

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    Top teams support in region of presence and rest of the world.
    Games collect millions of TV viewers. Introduce popular
    teams from different regions of the planet.

    Old Lady

    « Old Signora » .

    Must report another fact. In 1992 Manchester United founded the English Premier
    League.

    Best period came job Alex Ferguson. Team managed to win different prestigious titles.
    While about the past glory has only remembering.
    However Red Devils still could show good play.

    « Bayern »

    Composition first time originated in 1900. During time existence « Star of the South » achieved title most famous team FRG.

    Account about 60 major achievements.

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    List of the leading football clubs planet would incomplete without Real
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    football of the last century.

    The team achieved 65 ranks national class. To the list you can attribute 34 championships in the La Liga.
    Such results of competitors no.

    « Real Madrid » originated in 1902. After 18 years
    of work team gave title royal.

    Leading positions in Spanish football roster began to take over at the dawn of existence.
    Achieve this succeeded thanks to set reasons. The team is renowned for its comprehensive approach
    to training process. Mentors try to focus on several parameters:

    1. Physical condition of athletes.
    2. Selection.
    3. Tactics of action.

    Detailed work allows white win championships. About the merits of the composition successfully talk for hours.

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    Annual income high. Club earns on resale of players, advertising
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    Leading teams support in region of presence and rest of the world.
    Games attract millions of TV viewers. Introduce popular teams from different countries of the world.

    Juventus

    « Juventus » originated in 1897. Club became most titled.
    About awards you can talk long. In 2012 the club was recognised
    as the most famous in Italy.

    Sociologists performed independent research. It was possible to
    establish that more than 13 million people are sick of Juventus.
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    Football players of Juventus actively contribute charity projects.
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    Old Lady experienced crises. But the club could pass problems.

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    Manchester United

    List of best teams remain stripped without Manchester United.
    This team has become the most popular in the world.
    Fans can be found in many countries:

    • USA;
    • Russia;
    • France.

    Help team huge. Manchester United originated late 1870s.
    During the existence succeeded pass through many problems.

    Manchester United regarded the most most clubs of of English football in England .

    Must report additional fact. In the early 1990s Red Devils
    founded the English Premier League.

    Most successful stage got on job Alex Ferguson. Club managed to
    win different prestigious titles. At the moment about the past glory has only remembering.
    However Red Devils still be able to demonstrate good play.

    « Bayern »

    Composition first originated in 1900. During time existence « Bayern » achieved nickname most titled club FRG.
    Total about 60 significant awards.

    Currently fame came 2012. Club demonstrated excellent football.

    Bayern stayed in the leading lines in the national championship.
    Football players managed achieve excellent results at continental champions.

    Roster often helped other teams and ordinary people.
    Often Star of the South supported Munich 1860. Management implemented various
    options assistance:

    • economically attractive transitions;
    • free matches;
    • financial transactions.

    Now support works addressed. Team attempts to help people in need.

    Galacticos

    List of the leading football clubs planet be incomplete without Real
    Madrid. FIFA named this squad as the leader of football of the last century.

    The team achieved 65 titles national class.
    To the list you can add 34 first places in the
    La Liga. Similar results of competitors does not exist.

    « Galactikos » originated in 1902. Through 18 years of existence
    composition assigned title royal.

    Leadership in local football roster began to ta